A proline metabolism selection system and its application to the engineering of lipid biosynthesis in Chinese hamster ovary cells

A proline metabolism selection system and its application to the engineering of lipid biosynthesis in Chinese hamster ovary cells

Chinese hamster ovary (CHO) cells are the leading mammalian cell host employed to produce complex secreted recombinant biotherapeutics such as monoclonal antibodies (mAbs). Metabolic selection marker technologies (e.g. glutamine synthetase (GS) or dihydrofolate reductase (DHFR)) are routinely employ...

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Bibliographic Details
Main Authors: James D. Budge, Joanne Roobol, Gurdeep Singh, Théo Mozzanino, Tanya J. Knight, Jane Povey, Andrew Dean, Sarah J. Turner, Colin M. Jaques, Robert J. Young, Andrew J. Racher, C. Mark Smales
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Metabolic Engineering Communications
Subjects:
Chinese hamster ovary (CHO) cells
Metabolic selection system
Cell engineering
Proline metabolism
Biotherapeutic protein production
Online Access:http://www.sciencedirect.com/science/article/pii/S2214030121000195

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http://www.sciencedirect.com/science/article/pii/S2214030121000195

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