Intravital and whole-organ imaging reveals capture of melanoma-derived antigen by lymph node subcapsular macrophages leading to widespread deposition on follicular dendritic cells

Intravital and whole-organ imaging reveals capture of melanoma-derived antigen by lymph node subcapsular macrophages leading to widespread deposition on follicular dendritic cells

Aberrant antigens expressed by tumor cells, such as in melanoma, are often associated with humoral immune responses, which may in turn influence tumor progression. Despite recent data showing the central role of adaptive immune responses on cancer spread or control, it remains poorly understood wher...

Full description

Bibliographic Details
Main Authors: Federica eMoalli, Steven T Proulx, Reto eSchwenderer, Michael eDetmar, Christoph eSchlapbach, Jens Volker Stein
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Immunology
Subjects:
Follicular dendritic cells
Tumor-draining lymph node
Tumor-derived antigen deposition
Intravital twophoton imaging
whole-organ imaging
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00114/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00114/full

Similar Items