Geometric confinement is required for recovery and maintenance of chondrocyte phenotype in alginate
Human articular chondrocytes lose their native phenotype when expanded in traditional monolayer cultures. As a consequence, hydrogel encapsulation has been investigated as a means to maintain the natural phenotype. Alginate has been widely used for cartilage engineering as it has been shown to enabl...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
AIP Publishing LLC
2017-12-01
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| Series: | APL Bioengineering |
| Online Access: | http://dx.doi.org/10.1063/1.5006752 |