Deoxidized gulose moiety attenuates the pulmonary toxicity of 6'-deoxy-bleomycin Z without effect on its antitumor activity

Deoxidized gulose moiety attenuates the pulmonary toxicity of 6'-deoxy-bleomycin Z without effect on its antitumor activity

Bleomycins (BLMs) are broad-spectrum antitumor drugs, but the dose-dependent lung toxicity has restricted their therapeutic applications. Many efforts have contributed to develop novel BLM analogues, but mainly focused on single functional domain owing to the structural complexity of BLM. Benefit fr...

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Bibliographic Details
Main Authors: Jieqian Kong, Yi Xiong, Yanwen Duan, Xiangcheng Zhu
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Bleomycin and analogues
Sugar moiety
Antitumor activity
Pulmonary toxicity
ROS production
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222100007X

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http://www.sciencedirect.com/science/article/pii/S075333222100007X

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