Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate

Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate

Autotaxin (ATX) is a secreted enzyme, which produces extracellular lysophosphatidate (LPA) from lysophosphatidylcholine (LPC). LPA activates six G protein-coupled receptors and this is essential for vasculogenesis during embryonic development. ATX is also involved in wound healing and inflammation,...

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Bibliographic Details
Main Authors: Matthew G.K. Benesch, Yuan Y. Zhao, Jonathan M. Curtis, ToddP.W. McMullen, David N. Brindley
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Journal of Lipid Research
Subjects:
autotaxin inhibition
fluorescent substrate-3 assay
lysophosphatidylcholine
inflammation
cytokines
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520317259

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http://www.sciencedirect.com/science/article/pii/S0022227520317259

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