Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration

Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration

Migrating cells need to coordinate distinct leading and trailing edge dynamics but the underlying mechanisms are unclear. Here, we combine experiments and mathematical modeling to elaborate the minimal autonomous biochemical machinery necessary and sufficient for this dynamic coordination and cell m...

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Bibliographic Details
Main Authors: Alfonso Bolado-Carrancio, Oleksii S Rukhlenko, Elena Nikonova, Mikhail A Tsyganov, Anne Wheeler, Amaya Garcia-Munoz, Walter Kolch, Alex von Kriegsheim, Boris N Kholodenko
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
cell migration
rho gtpases
mathematical modeling
oscillations and waves
nonlinear dynamics
Online Access:https://elifesciences.org/articles/58165

Internet

https://elifesciences.org/articles/58165

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