Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity

Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity

Abstract Parkinson disease (PD) is the second most common neurodegenerative disorder and the leading neurodegenerative cause of motor disability. Pathologic accumulation of aggregated alpha synuclein (AS) protein in brain, and imbalance in the nigrostriatal system due to the loss of dopaminergic neu...

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Bibliographic Details
Main Authors: Asad Jan, Brandon Jansonius, Alberto Delaidelli, Forum Bhanshali, Yi Andy An, Nelson Ferreira, Lisa M. Smits, Gian Luca Negri, Jens C. Schwamborn, Poul H. Jensen, Ian R. Mackenzie, Stefan Taubert, Poul H. Sorensen
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Acta Neuropathologica Communications
Subjects:
eEF2K
Parkinson disease
Alpha synuclein
Oxidative stress
Neurotoxicity
Online Access:http://link.springer.com/article/10.1186/s40478-018-0554-9

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http://link.springer.com/article/10.1186/s40478-018-0554-9

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