Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance

Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance

Objective: PARKIN is an E3 ubiquitin ligase that regulates mitochondrial quality control through a process called mitophagy. Recent human and rodent studies suggest that loss of hepatic mitophagy may occur during the pathogenesis of obesity-associated fatty liver and contribute to changes in mitocho...

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Bibliographic Details
Main Authors: Lia R. Edmunds, Bingxian Xie, Amanda M. Mills, Brydie R. Huckestein, Ramya Undamatla, Anjana Murali, Martha M. Pangburn, James Martin, Ian Sipula, Brett A. Kaufman, Iain Scott, Michael J. Jurczak
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Molecular Metabolism
Subjects:
Parkin
Mitochondria
Mitophagy
Bioenergetics
Hepatic steatosis
Insulin resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820301253

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http://www.sciencedirect.com/science/article/pii/S2212877820301253

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