Analytical methodology and pharmacokinetic study of elagolix in plasma of rats using a newly developed UPLC-MS/MS assay

Elagolix, as a competitive gonadotropin-releasing hormone (GnRH) receptor antagonist, has been recently approved by the US FDA for the management of moderate to severe pain due to endometriosis in women. In this study, we developed and verified an analysis assay to detect the concentration level of...

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Bibliographic Details
Main Authors: Qiong Wang, Er-Min Gu, Chaojie Chen, Ren-ai Xu, Shunbin Luo
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Arabian Journal of Chemistry
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535221002501