Local Cisplatin Delivery in Mouse Reliably Models Sensorineural Ototoxicity Without Systemic Adverse Effects

Local Cisplatin Delivery in Mouse Reliably Models Sensorineural Ototoxicity Without Systemic Adverse Effects

Cisplatin is a lifesaving chemotherapeutic drug with marked ototoxic adverse effects. Cisplatin-induced hearing loss affects a significant part of cancer-surviving patients and is an unmet clinical need with important socioeconomic consequences. Unfortunately, in current preclinical animal models of...

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Bibliographic Details
Main Authors: German Nacher-Soler, Sébastien Lenglet, Marta Coelho, Aurélien Thomas, François Voruz, Karl-Heinz Krause, Pascal Senn, Francis Rousset
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
refinement
animal welfare
middle ear delivery
cisplatin ototoxicity
cochlea
mass spectrometry
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.701783/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2021.701783/full

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