Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy

Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy

Homozygous deletion (HD) of the tumor suppressor gene CDKN2A is the most frequent genetic alteration in malignant pleural mesothelioma and is also frequent in non-small cell lung cancers. This HD is often accompanied by the HD of the type I interferons (IFN I) genes that are located closed to the CD...

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Bibliographic Details
Main Authors: Marion Grard, Camille Chatelain, Tiphaine Delaunay, Elvire Pons-Tostivint, Jaafar Bennouna, Jean-François Fonteneau
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
lung cancer
mesothelioma
type I interferon
CDKN2A (p16)
homozygous deletion
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.695770/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.695770/full

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