Repression of GSK3 restores NK cell cytotoxicity in AML patients

Repression of GSK3 restores NK cell cytotoxicity in AML patients

Natural killer cells of acute myeloid leukaemia patients lack cytotoxic activity. Here the authors show that these cells have elevated GSK3β, and that its inhibition prolongs survival of mice transplanted with human AML and stimulates NK cytotoxicity via increased adhesion of NK cells to their targe...

Full description

Bibliographic Details
Main Authors: Reshmi Parameswaran, Parameswaran Ramakrishnan, Stephen A. Moreton, Zhiqiang Xia, Yongchun Hou, Dean A. Lee, Kalpana Gupta, Marcos deLima, Rose C. Beck, David N. Wald
Format: Article
Language:English
Published: Nature Publishing Group 2016-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11154

Internet

https://doi.org/10.1038/ncomms11154

Similar Items