Smad4-dependent pathways control basement membrane deposition and endodermal cell migration at early stages of mouse development

<p>Abstract</p> <p>Background</p> <p>Smad4 mutant embryos arrest shortly after implantation and display a characteristic shortened proximodistal axis, a significantly reduced epiblast, as well as a thickened visceral endoderm layer. Conditional rescue experiments demons...

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Bibliographic Details
Main Authors: Taylor Jennifer M, Biondi Christine A, Costello Ita, Bikoff Elizabeth K, Robertson Elizabeth J
Format: Article
Language:English
Published: BMC 2009-10-01
Series:BMC Developmental Biology
Online Access:http://www.biomedcentral.com/1471-213X/9/54