Structures of Merkel cell polyomavirus VP1 complexes define a sialic acid binding site required for infection.

Structures of Merkel cell polyomavirus VP1 complexes define a sialic acid binding site required for infection.

The recently discovered human Merkel cell polyomavirus (MCPyV or MCV) causes the aggressive Merkel cell carcinoma (MCC) in the skin of immunocompromised individuals. Conflicting reports suggest that cellular glycans containing sialic acid (Neu5Ac) may play a role in MCPyV infectious entry. To addres...

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Bibliographic Details
Main Authors: Ursula Neu, Holger Hengel, Bärbel S Blaum, Rachel M Schowalter, Dennis Macejak, Michel Gilbert, Warren W Wakarchuk, Akihiro Imamura, Hiromune Ando, Makoto Kiso, Niklas Arnberg, Robert L Garcea, Thomas Peters, Christopher B Buck, Thilo Stehle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3406085?pdf=render

Internet

http://europepmc.org/articles/PMC3406085?pdf=render

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