Structural Insight into the Contributions of the N-Terminus and Key Active-Site Residues to the Catalytic Efficiency of Glutamine Synthetase 2

Structural Insight into the Contributions of the N-Terminus and Key Active-Site Residues to the Catalytic Efficiency of Glutamine Synthetase 2

Glutamine synthetase (GS) catalyzes the condensation of ammonia and glutamate, along with ATP, to form glutamine. Despite extensive studies on GSs from eukaryotes and prokaryotes, the roles of the N-terminus and other structural features in catalysis remain unclear. Here we report the decameric stru...

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Bibliographic Details
Main Authors: Wen-Ting Chen, Hsin-Yu Yang, Chih-Yu Lin, Yi-Zong Lee, Szu-Chin Ma, Wei-Cheng Chen, Hsien-Sheng Yin
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Biomolecules
Subjects:
glutamine synthetase
<i>Drosophila melanogaster</i>
enzyme kinetics
crystal structure
circular dichroism
Online Access:https://www.mdpi.com/2218-273X/10/12/1671

Internet

https://www.mdpi.com/2218-273X/10/12/1671

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