Structural Insight into the Recognition of r(UAG) by Musashi-1 RBD2, and Construction of a Model of Musashi-1 RBD1-2 Bound to the Minimum Target RNA

Structural Insight into the Recognition of r(UAG) by Musashi-1 RBD2, and Construction of a Model of Musashi-1 RBD1-2 Bound to the Minimum Target RNA

Musashi-1 (Msi1) controls the maintenance of stem cells and tumorigenesis through binding to its target mRNAs and subsequent translational regulation. Msi1 has two RNA-binding domains (RBDs), RBD1 and RBD2, which recognize r(GUAG) and r(UAG), respectively. These minimal recognition sequences are con...

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Bibliographic Details
Main Authors: Ryo Iwaoka, Takashi Nagata, Kengo Tsuda, Takao Imai, Hideyuki Okano, Naohiro Kobayashi, Masato Katahira
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:Molecules
Subjects:
RNA-binding protein
Msi1
solution structure determination
protein-RNA complex
Online Access:https://www.mdpi.com/1420-3049/22/7/1207

Internet

https://www.mdpi.com/1420-3049/22/7/1207

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