Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP

Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP

Intramembrane proteases (IMPs) are a unique class of proteases that catalyze the proteolysis within the membrane and regulate diverse cellular processes in various organisms. RseP, an Escherichia coli site-2 protease (S2P) family IMP, is involved in the regulation of an extracytoplasmic stress respo...

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Bibliographic Details
Main Authors: Takuya Miyake, Yohei Hizukuri, Yoshinori Akiyama
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Microbiology
Subjects:
metallopeptidase
PDZ domain
regulated intramembrane proteolysis
extracytoplasmic stress response
site-2 protease
substrate recognition and specificity
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.607381/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2020.607381/full

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