Silencing and nuclear repositioning of the lambda5 gene locus at the pre-B cell stage requires Aiolos and OBF-1.

Silencing and nuclear repositioning of the lambda5 gene locus at the pre-B cell stage requires Aiolos and OBF-1.

The chromatin regulator Aiolos and the transcriptional coactivator OBF-1 have been implicated in regulating aspects of B cell maturation and activation. Mice lacking either of these factors have a largely normal early B cell development. However, when both factors are eliminated simultaneously a blo...

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Bibliographic Details
Main Authors: Alexander Karnowski, Chun Cao, Gabriele Matthias, Sebastian Carotta, Lynn M Corcoran, Inga-Lill Martensson, Jane A Skok, Patrick Matthias
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2571989?pdf=render

Internet

http://europepmc.org/articles/PMC2571989?pdf=render

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