Significant structural but not physiological changes in cortical neurons of 12-month-old Tg2576 mice
Amyloid-beta (Aβ) plays a key role in the etiology of Alzheimer's disease, and pyramidal cell dendrites exposed to Aβ exhibit dramatic structural alterations, including reduced dendritic spine densities. To determine whether such structural alterations lead to electrophysiological changes, whol...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2008-11-01
|
| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S096999610800168X |