A genome-wide screen for genetic variants that modify the recruitment of REST to its target genes.

A genome-wide screen for genetic variants that modify the recruitment of REST to its target genes.

Increasing numbers of human diseases are being linked to genetic variants, but our understanding of the mechanistic links leading from DNA sequence to disease phenotype is limited. The majority of disease-causing nucleotide variants fall within the non-protein-coding portion of the genome, making it...

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Bibliographic Details
Main Authors: Rory Johnson, Nadine Richter, Gireesh K Bogu, Akshay Bhinge, Siaw Wei Teng, Siew Hua Choo, Lise O Andrieux, Cinzia de Benedictis, Ralf Jauch, Lawrence W Stanton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3320604?pdf=render

Internet

http://europepmc.org/articles/PMC3320604?pdf=render

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