Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

Summary: Neurohormonal overactivation plays an important role in pulmonary hypertension (PH). In this context, renal denervation, which aims to inhibit the neurohormonal systems, may be a promising adjunct therapy in PH. In this proof-of-concept study, we have demonstrated in 2 experimental models o...

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Main Authors: Denielli da Silva Gonçalves Bos, MSc, Chris Happé, MSc, Ingrid Schalij, BSc, Wioletta Pijacka, PhD, Julian F.R. Paton, PhD, Christophe Guignabert, PhD, Ly Tu, PhD, Raphaël Thuillet, BSc, Harm-Jan Bogaard, MD, PhD, Albert C. van Rossum, MD, PhD, Anton Vonk-Noordegraaf, MD, PhD, Frances S. de Man, PhD, M. Louis Handoko, MD, PhD
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X16301668

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http://www.sciencedirect.com/science/article/pii/S2452302X16301668

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