IL-4 Is a Key Requirement for IL-4- and IL-4/IL-13-Expressing CD4 Th2 Subsets in Lung and Skin

IL-4 Is a Key Requirement for IL-4- and IL-4/IL-13-Expressing CD4 Th2 Subsets in Lung and Skin

Although IL-4 is long associated with CD4 Th2 immune responses, its role in Th2 subset development in non-lymphoid tissues is less clear. We sought to better define IL-4’s role in CD4 Th2 responses by using transgenic mice that express a dual IL-4 AmCyan/IL-13 DsRed (IL-4AC/IL-13DR) fluorescent repo...

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Bibliographic Details
Main Authors: Melanie Sarah Prout, Ryan L. Kyle, Franca Ronchese, Graham Le Gros
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
Th2
IL-4
IL-13
skin
lymph node
lung
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01211/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01211/full

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