Increasing transforming growth factor-beta concentrations with age decrease apelin in the rat rotator cuff

Abstract Background The rotator cuff undergoes natural degeneration with age, leading to age-related rotator cuff tear; however, the precise mechanism remains unclear. Transforming growth factor-beta (TGF-β) concentrations rise with age and TGF-β contributes to the pathophysiology of skeletal muscle...

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Bibliographic Details
Main Authors: Ryo Tazawa, Kentaro Uchida, Tomonori Kenmoku, Mitsufumi Nakawaki, Kyoko Muneshige, Daisuke Ishii, Gen Inoue, Masashi Takaso
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Online Access:https://doi.org/10.1186/s13018-021-02675-0