The Physiology of Obese-Hyperglycemic Mice [ob/ob Mice]
This review summarizes key aspects of what has been learned about the physiology of leptin deficiency as it can be observed in obese-hyperglycemic ob/ob mice. These mice lack functional leptin. They are grossly overweight and hyperphagic, particularly at young ages, and develop severe insulin resist...
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2007-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2007.117 |