Leukotriene B4 pathway activation and atherosclerosis in obstructive sleep apnea[S]

Leukotriene B4 pathway activation and atherosclerosis in obstructive sleep apnea[S]

Leukotriene B4 (LTB4) production increases in obstructive sleep apnea syndrome (OSA) and is linked to early vascular remodeling, the mechanism of which is unknown. The objective of this study was to to determine the molecular mechanisms of LTB4 pathway activation in polymorphonuclear cells (PMNs) an...

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Bibliographic Details
Main Authors: Françoise Stanke-Labesque, Jean-Louis Pépin, Tiphaine de Jouvencel, Claire Arnaud, Jean-Philippe Baguet, Marcelo H. Petri, Renaud Tamisier, Jean François Jourdil, Patrick Lévy, Magnus Bäck
Format: Article
Language:English
Published: Elsevier 2012-09-01
Series:Journal of Lipid Research
Subjects:
arachidonic acid
eicosanoids
granulocytes
intermittent hypoxia
lipoxygenase
vascular remodeling
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752041836X

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http://www.sciencedirect.com/science/article/pii/S002222752041836X

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