Application of Multilayer Evidence for Annotation of C-Terminal <i>BRCA2</i> Variants

Application of Multilayer Evidence for Annotation of C-Terminal <i>BRCA2</i> Variants

The clinical relevance of the <i>BRCA2</i> C-terminal stop codon variants is controversial. The pathogenic role of the germline <i>BRCA2</i> c.9976A>T and c.10095delinsGAATTATATCT variants in hereditary breast and ovarian cancer (HBOC) patients was evaluated. An associatio...

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Bibliographic Details
Main Authors:	Henriett Butz, János Papp, Anikó Bozsik, Lilla Krokker, Tímea Pócza, Edit Oláh, Attila Patócs
Format:	Article
Language:	English
Published:	MDPI AG 2021-02-01
Series:	Cancers
Subjects:	<i>BRCA2</i> breast cancer ovarian cancer p.K3326* cancer predisposition NGS
Online Access:	https://www.mdpi.com/2072-6694/13/4/881

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