Synthesis and biological evaluation of 2-(4-methylsulfonyl phenyl) indole derivatives: multi-target compounds with dual antimicrobial and anti-inflammatory activities

Synthesis and biological evaluation of 2-(4-methylsulfonyl phenyl) indole derivatives: multi-target compounds with dual antimicrobial and anti-inflammatory activities

Abstract Three series of 2-(4-methylsulfonylphenyl) indole derivatives have been designed and synthesized. The synthesized compounds were assessed for their antimicrobial, COX inhibitory and anti-inflammatory activities. Compound 7g was identified to be the most potent antibacterial candidate agains...

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Bibliographic Details
Main Authors: Ahmed M. M. Shaker, Eman K. A. Abdelall, Khaled R. A. Abdellatif, Hamdy M. Abdel-Rahman
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Chemistry
Subjects:
Antimicrobial
Indomethacin analogues
COX-2 inhibitors
Nitric oxide
Anti-inflammatory
Online Access:http://link.springer.com/article/10.1186/s13065-020-00675-5

Internet

http://link.springer.com/article/10.1186/s13065-020-00675-5

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