A novel mouse model of obstructive sleep apnea by bulking agent-induced tongue enlargement results in left ventricular contractile dysfunction.

A novel mouse model of obstructive sleep apnea by bulking agent-induced tongue enlargement results in left ventricular contractile dysfunction.

<h4>Aims</h4>Obstructive sleep apnea (OSA) is a widespread disease with high global socio-economic impact. However, detailed pathomechanisms are still unclear, partly because current animal models of OSA do not simulate spontaneous airway obstruction. We tested whether polytetrafluoroeth...

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Bibliographic Details
Main Authors: Simon Lebek, Philipp Hegner, Christian Schach, Kathrin Reuthner, Maria Tafelmeier, Lars Siegfried Maier, Michael Arzt, Stefan Wagner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0243844

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https://doi.org/10.1371/journal.pone.0243844

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