Tailored Modulation of Cellular Pro-inflammatory Responses With Disaccharide Lipid A Mimetics

Tailored Modulation of Cellular Pro-inflammatory Responses With Disaccharide Lipid A Mimetics

Pro-inflammatory signaling mediated by Toll-like receptor 4 (TLR4)/myeloid differentiation-2 (MD-2) complex plays a crucial role in the instantaneous protection against infectious challenge and largely contributes to recovery from Gram-negative infection. Activation of TLR4 also boosts the adaptive...

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Bibliographic Details
Main Authors: Holger Heine, Florian Adanitsch, Tina Tinkara Peternelj, Mira Haegman, Christoph Kasper, Simon Ittig, Rudi Beyaert, Roman Jerala, Alla Zamyatina
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
synthetic TLR4 agonist
immunomodulation
lipopolysaccharide
Toll-like Receptor 4
TLR4/MD-2 complex activation
potential adjuvant
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.631797/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.631797/full

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