Genetic variation of the RASGRF1 regulatory region affects human hippocampus-dependent memory

Genetic variation of the RASGRF1 regulatory region affects human hippocampus-dependent memory

The guanine nucleotide exchange factor RASGRF1 is an important regulator of intracellular signaling and neural plasticity in the brain. RASGRF1-deficient mice exhibit a complex phenotype with learning deficits and ocular abnormalities. Also in humans, a genome-wide association study has identified t...

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Bibliographic Details
Main Authors: Adriana eBarman, Anne eAssmann, Sylvia eRichter, Joram eSoch, Hartmut eSchütze, Torsten eWüstenberg, Anna eDeibele, Marieke eKlein, Anni eRichter, Gusalija eBehnisch, Emrah eDuzel, Martin eZenker, Constanze I Seidenbecher, Björn H Schott
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Human Neuroscience
Subjects:
Genetic Variation
Hippocampus
fMRI
episodic memory
Rasgrf1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00260/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00260/full

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