Down-regulation of the tumor suppressor miR-34a contributes to head and neck cancer by up-regulating the MET oncogene and modulating tumor immune evasion

Down-regulation of the tumor suppressor miR-34a contributes to head and neck cancer by up-regulating the MET oncogene and modulating tumor immune evasion

Abstract Background MicroRNAs (miRs) have been shown to play an important role in tumorigenesis, including in head and neck squamous cell carcinoma (HNSCC). The miR-34 family is thought to play a role in tumor suppression, but the exact mechanism of their action in HNSCC is not well understood. More...

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Bibliographic Details
Main Authors: Xun Wu, Yi-Shing Lisa Cheng, Mathew Matthen, Angela Yoon, Gary K. Schwartz, Shashi Bala, Alison M. Taylor, Fatemeh Momen-Heravi
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Head and neck cancer
miR-34a
Aneuploidy
P53
MET
micoRNA
Online Access:https://doi.org/10.1186/s13046-021-01865-2

Internet

https://doi.org/10.1186/s13046-021-01865-2

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