Mechanism of Regulation of Big-Conductance Ca2+-Activated K+ Channels by mTOR Complex 2 in Podocytes

Mechanism of Regulation of Big-Conductance Ca2+-Activated K+ Channels by mTOR Complex 2 in Podocytes

Podocytes, dynamic polarized cells wrapped around glomerular capillaries, are an essential component of the glomerular filtration barrier. BK channels consist of one of the slit diaphragm (SD) proteins in podocytes, interact with the actin cytoskeleton, and play vital roles in glomerular filtration....

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Bibliographic Details
Main Authors: Yinhang Wang, Jie Tao, Mengling Wang, Licai Yang, Fengling Ning, Hong Xin, Xudong Xu, Hui Cai, Weiguang Zhang, Ker Yu, Xuemei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Physiology
Subjects:
BK channels
mTORC2
Akt
SGK1
PKCα
podocyte
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00167/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00167/full

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