Molecular and evolutionary insights into the structural organization of cation chloride cotransporters

Molecular and evolutionary insights into the structural organization of cation chloride cotransporters

Cation chloride cotransporters (CCC) play an essential role for neuronal chloride homeostasis. KCC2 is the principal Cl--extruder, whereas NKCC1 is the major Cl--uptake mechanism in many neurons. As a consequence, the action of the inhibitory neurotransmitters GABA and glycine strongly depend on the...

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Bibliographic Details
Main Authors: Anna-Maria eHartmann, Hans Gerd Nothwang
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Phosphorylation
evolution
Structure
modeling
Oligomerization
synaptic inhibition
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00470/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00470/full

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