Computational and experimental validation of B and T-cell epitopes of the in vivo immune response to a novel malarial antigen.

Vaccine development efforts will be guided by algorithms that predict immunogenic epitopes. Such prediction methods rely on classification-based algorithms that are trained against curated data sets of known B and T cell epitopes. It is unclear whether this empirical approach can be applied prospect...

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Bibliographic Details
Main Authors: Elke S Bergmann-Leitner, Sidhartha Chaudhury, Nicholas J Steers, Mark Sabato, Vito Delvecchio, Anders S Wallqvist, Christian F Ockenhouse, Evelina Angov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3745447?pdf=render