Substance P-modified human serum albumin nanoparticles loaded with paclitaxel for targeted therapy of glioma

Substance P-modified human serum albumin nanoparticles loaded with paclitaxel for targeted therapy of glioma

The blood–brain barrier (BBB) and the poor ability of many drugs to cross that barrier greatly limits the efficacy of chemotherapies for glioblastoma multiforme (GBM). The present study exploits albumin as drug delivery vehicle to promote the chemotherapeutic efficacy of paclitaxel (PTX) by improvin...

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Bibliographic Details
Main Authors: Chunhui Ruan, Lisha Liu, Yifei Lu, Yu Zhang, Xi He, Xinli Chen, Yujie Zhang, Qinjun Chen, Qin Guo, Tao Sun, Chen Jiang
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Human serum albumin
Paclitaxel
Drug delivery
Substance P
Blood–brain barrier
Glioma
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383517302824

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http://www.sciencedirect.com/science/article/pii/S2211383517302824

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