The CXCR4–STAT3–IL-10 Pathway Controls the Immunoregulatory Function of Chronic Lymphocytic Leukemia and Is Modulated by Lenalidomide

The CXCR4–STAT3–IL-10 Pathway Controls the Immunoregulatory Function of Chronic Lymphocytic Leukemia and Is Modulated by Lenalidomide

Chronic lymphocytic leukemia (CLL) cells possess regulatory functions comparable to those of normal B10 cells, a regulatory B cell subset that suppresses effector T-cell function through STAT3-mediated IL-10 production. However, the mechanisms governing IL-10 production by CLL cells are not fully un...

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Bibliographic Details
Main Authors: Hila Shaim, Zeev Estrov, David Harris, Mayra Hernandez Sanabria, Zhiming Liu, Peter Ruvolo, Phillip A. Thompson, Alessandra Ferrajoli, May Daher, Jan Burger, Muharrem Muftuoglu, Nobuhiko Imahashi, Li Li, Enli Liu, Abdullah Saleh Alsuliman, Rafet Basar, Lucila Nassif Kerbauy, Catherine Sobieski, Elif Gokdemir, Kayo Kondo, William Wierda, Michael Keating, Elizabeth J. Shpall, Katayoun Rezvani
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
chronic lymphocytic leukemia
B10
regulatory B cells
immunosuppression
STAT3
IL-10
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01773/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01773/full

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