MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult

<p>Abstract</p> <p>Background</p> <p>An endotoxin insult mimics a severe peripheral infection and recent evidence suggests that a single exposure can cause long-term cognitive deficits. A peripheral injection of LPS results in production of pro-inflammatory cytokines, s...

Full description

Bibliographic Details
Main Authors: Karpus William J, Thompson Wendy L, Van Eldik Linda J
Format: Article
Language:English
Published: BMC 2008-08-01
Series:Journal of Neuroinflammation
Online Access:http://www.jneuroinflammation.com/content/5/1/35