Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade

Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade

Coronaries are essential for myocardial growth and heart function. Notch is crucial for mouse embryonic angiogenesis, but its role in coronary development remains uncertain. We show Jag1, Dll4 and activated Notch1 receptor expression in sinus venosus (SV) endocardium. Endocardial Jag1 removal blocks...

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Bibliographic Details
Main Authors: Stanislao Igor Travisano, Vera Lucia Oliveira, Belén Prados, Joaquim Grego-Bessa, Rebeca Piñeiro-Sabarís, Vanesa Bou, Manuel J Gómez, Fátima Sánchez-Cabo, Donal MacGrogan, José Luis de la Pompa
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
coronaries
sinus venosus
erial-venous differentiation
vessel morphogenesis
NOTCH
EphrinB2
Online Access:https://elifesciences.org/articles/49977

Internet

https://elifesciences.org/articles/49977

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