Dna2 nuclease-helicase structure, mechanism and regulation by Rpa

Dna2 nuclease-helicase structure, mechanism and regulation by Rpa

The Dna2 nuclease-helicase maintains genomic integrity by processing DNA double-strand breaks, Okazaki fragments and stalled replication forks. Dna2 requires ssDNA ends, and is dependent on the ssDNA-binding protein Rpa, which controls cleavage polarity. Here we present the 2.3 Å structure of intact...

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Bibliographic Details
Main Authors: Chun Zhou, Sergei Pourmal, Nikola P Pavletich
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-10-01
Series:eLife
Subjects:
Dna2
Rpa
DNA replication
nuclease
helicase
DNA end resection
Online Access:https://elifesciences.org/articles/09832

Internet

https://elifesciences.org/articles/09832

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