The production method affects the efficacy of platelet derivatives to expand mesenchymal stromal cells in vitro

The production method affects the efficacy of platelet derivatives to expand mesenchymal stromal cells in vitro

Abstract Background The use of fetal bovine serum (FBS) as a media supplement for the ex vivo expansion of bone-marrow derived mesenchymal stromal cells (BM-MSC) has been discouraged by regulatory agencies, due to the risk of transmitting zoonoses and to elicit immune reactions in the host once tran...

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Bibliographic Details
Main Authors: Martina Bernardi, Francesco Agostini, Katia Chieregato, Eliana Amati, Cristina Durante, Mario Rassu, Marco Ruggeri, Sabrina Sella, Elisabetta Lombardi, Mario Mazzucato, Giuseppe Astori
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Journal of Translational Medicine
Subjects:
Platelet lysate
Platelet releasate
Mesenchymal stromal cells
Mesenchymal stem cells
Ex vivo expansion
Fetal bovine serum
Online Access:http://link.springer.com/article/10.1186/s12967-017-1185-9

Internet

http://link.springer.com/article/10.1186/s12967-017-1185-9

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