Inherent promoter bidirectionality facilitates maintenance of sequence integrity and transcription of parasitic DNA in mammalian genomes

<p>Abstract</p> <p>Background</p> <p>Many mammalian genes are arranged in a bidirectional manner, sharing a common promoter and regulatory elements. This is especially true for promoters containing a CpG island, usually unmethylated and associated with an 'open...

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Bibliographic Details
Main Authors: Kalitsis Paul, Saffery Richard
Format: Article
Language:English
Published: BMC 2009-10-01
Series:BMC Genomics
Online Access:http://www.biomedcentral.com/1471-2164/10/498