ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2

ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2

Here, we describe the initial characterization of Abcg4−/− mice and identify overlapping functions of ABCG4 and ABCG1 in the brain. Histological examination of tissues from Abcg4+/−/nlsLacZ and Abcg1+/−/nlsLacZ mice demonstrates that coexpression of Abcg4 and Abcg1 is restricted to neurons and astro...

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Bibliographic Details
Main Authors: Paul T. Tarr, Peter A. Edwards
Format: Article
Language:English
Published: Elsevier 2008-01-01
Series:Journal of Lipid Research
Subjects:
liver X receptor
ATP binding cassette transporters G1 and G4
sterol-regulatory element binding protein 2
central nervous system
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520428925

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http://www.sciencedirect.com/science/article/pii/S0022227520428925

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