The Insect Ortholog of the Human Orphan Cytokine Receptor CRLF3 Is a Neuroprotective Erythropoietin Receptor

The Insect Ortholog of the Human Orphan Cytokine Receptor CRLF3 Is a Neuroprotective Erythropoietin Receptor

The cytokine erythropoietin (Epo) mediates various cell homeostatic responses to environmental challenges and pathological insults. While stimulation of vertebrate erythrocyte production is mediated by homodimeric “classical” Epo receptors, alternative receptors are involved in neuroprotection. Howe...

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Bibliographic Details
Main Authors: Nina Hahn, Debbra Y. Knorr, Johannes Liebig, Liane Wüstefeld, Karsten Peters, Marita Büscher, Gregor Bucher, Hannelore Ehrenreich, Ralf Heinrich
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
erythropoietin
non-erythropoietic splice variant
neuroprotection
cytokine receptor
primary neuronal cell culture
RNA interference
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00223/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00223/full

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