PHYRN: a robust method for phylogenetic analysis of highly divergent sequences.

PHYRN: a robust method for phylogenetic analysis of highly divergent sequences.

Both multiple sequence alignment and phylogenetic analysis are problematic in the "twilight zone" of sequence similarity (≤ 25% amino acid identity). Herein we explore the accuracy of phylogenetic inference at extreme sequence divergence using a variety of simulated data sets. We evaluate...

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Bibliographic Details
Main Authors: Gaurav Bhardwaj, Kyung Dae Ko, Yoojin Hong, Zhenhai Zhang, Ngai Lam Ho, Sree V Chintapalli, Lindsay A Kline, Matthew Gotlin, David Nicholas Hartranft, Morgen E Patterson, Foram Dave, Evan J Smith, Edward C Holmes, Randen L Patterson, Damian B van Rossum
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22514627/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22514627/?tool=EBI

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