Alleviation of Ischemia-Induced Brain Edema by Activation of the Central Histaminergic System in Rats

We have reported that facilitation of central histaminergic activity prevents the development of ischemia-induced brain injury. Since cerebral edema is a major cause of brain damage, we studied effects on brain edema of postischemic administration of l-histidine, a precursor of histamine, and thiope...

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Bibliographic Details
Main Authors: Yumi Irisawa, Naoto Adachi, Keyue Liu, Tatsuru Arai, Takumi Nagaro
Format: Article
Language:English
Published: Elsevier 2008-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319313817