Single Nucleotide Polymorphism in KIR2DL1 Is Associated With HLA-C Expression in Global Populations

Single Nucleotide Polymorphism in KIR2DL1 Is Associated With HLA-C Expression in Global Populations

Regulation of NK cell activity is mediated through killer-cell immunoglobulin-like receptors (KIR) ability to recognize human leukocyte antigen (HLA) class I molecules as ligands. Interaction of KIR and HLA is implicated in viral infections, autoimmunity, and reproduction and there is growing eviden...

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Bibliographic Details
Main Authors: Luciana de Brito Vargas, Renata M. Dourado, Leonardo M. Amorim, Brenda Ho, Verónica Calonga-Solís, Hellen C. Issler, Wesley M. Marin, Marcia H. Beltrame, Maria Luiza Petzl-Erler, Jill A. Hollenbach, Danillo G. Augusto
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
NK cells
KIR
natural selection
linkage disequilibrium
coevolution
expression
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01881/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01881/full

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