Shiga Toxin Uptake and Sequestration in Extracellular Vesicles Is Mediated by Its B-Subunit

Shiga Toxin Uptake and Sequestration in Extracellular Vesicles Is Mediated by Its B-Subunit

Shiga toxin (Stx)-stimulated blood cells shed extracellular vesicles (EVs) which can transfer the toxin to the kidneys and lead to hemolytic uremic syndrome. The toxin can be taken up by renal cells within EVs wherein the toxin is released, ultimately leading to cell death. The mechanism by which St...

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Bibliographic Details
Main Authors: Annie Willysson, Anne-lie Ståhl, Daniel Gillet, Julien Barbier, Jean-Christophe Cintrat, Valérie Chambon, Anne Billet, Ludger Johannes, Diana Karpman
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Toxins
Subjects:
Shiga toxin
extracellular vesicles
red blood cells
HeLa cells
globotriaosylceramide
Online Access:https://www.mdpi.com/2072-6651/12/7/449

Internet

https://www.mdpi.com/2072-6651/12/7/449

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