Sulfur Dioxide Activates Cl-/HCO3- Exchanger via Sulphenylating AE2 to Reduce Intracellular pH in Vascular Smooth Muscle Cells

Sulfur Dioxide Activates Cl-/HCO3- Exchanger via Sulphenylating AE2 to Reduce Intracellular pH in Vascular Smooth Muscle Cells

Sulfur dioxide (SO2) is a colorless and irritating gas. Recent studies indicate that SO2 acts as the gas signal molecule and inhibits vascular smooth muscle cell (VSMC) proliferation. Cell proliferation depends on intracellular pH (pHi). Transmembrane cystein mutation of Na+- independent Cl-/HCO3- e...

Full description

Bibliographic Details
Main Authors: Yi Wang, Xiuli Wang, Selena Chen, Xiaoyu Tian, Lulu Zhang, Yaqian Huang, Chaoshu Tang, Junbao Du, Hongfang Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Pharmacology
Subjects:
sulfur dioxide
vascular smooth muscle cell
intracellular pH
Cl-/HCO3- exchanger
AE2 sulphenylation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00313/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00313/full

Similar Items