The distinct conformational dynamics of K-Ras and H-Ras A59G.

The distinct conformational dynamics of K-Ras and H-Ras A59G.

Ras proteins regulate signaling cascades crucial for cell proliferation and differentiation by switching between GTP- and GDP-bound conformations. Distinct Ras isoforms have unique physiological functions with individual isoforms associated with different cancers and developmental diseases. Given th...

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Bibliographic Details
Main Authors: Suryani Lukman, Barry J Grant, Alemayehu A Gorfe, Guy H Grant, J Andrew McCammon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2936511?pdf=render

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http://europepmc.org/articles/PMC2936511?pdf=render

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