Reverse Gyrase Functions in Genome Integrity Maintenance by Protecting DNA Breaks In Vivo

Reverse Gyrase Functions in Genome Integrity Maintenance by Protecting DNA Breaks In Vivo

Reverse gyrase introduces positive supercoils to circular DNA and is implicated in genome stability maintenance in thermophiles. The extremely thermophilic crenarchaeon Sulfolobus encodes two reverse gyrase proteins, TopR1 (topoisomerase reverse gyrase 1) and TopR2, whose functions in thermophilic l...

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Bibliographic Details
Main Authors: Wenyuan Han, Xu Feng, Qunxin She
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:International Journal of Molecular Sciences
Subjects:
reverse gyrase
Sulfolobus
MMS
genomic DNA breakage
genomic DNA degradation
CRISPRi approach
Online Access:http://www.mdpi.com/1422-0067/18/7/1340

Internet

http://www.mdpi.com/1422-0067/18/7/1340

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